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2020a), although its precise physiological role is not fully understood

However, the period of piling on the pounds post-treatment is likely to plateau, with patients managing to keep a quarter of the weight lost off

Consider increased clinical or laboratory monitoring for medications that have a narrow therapeutic index or that require clinical monitoring Use in Specific Populations Pregnancy: Available data with semaglutide use in pregnant women are not sufficient to determine a drug associated risk for major birth defects, miscarriage, or other adverse maternal or fetal outcomes

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This study also demonstrated that the effects of the tri-agonist are dependent on an excess of nutrient storage as weight and food intake were not altered in lean mice even after chronic treatment with the tri-agonist