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Hong J-H, Kim D-H, Lee M-K (2021) Glucolipotoxicity and GLP-1 secretion

We report herein a series of pharmacological and molecular studies in two validated mouse models of PCOS, generated by gestational (PNA) or postweaning (PWA) androgenization, addressing the effects of GLP1-based multi-agonist therapies on metabolic and reproductive traits of PCOS

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Validation of syeA knockdown To verify that the anti- syeA PNA reduces syeA transcripts, RNA was extracted from single, whole aphids 24 h after injection, with 12 anti- syeA and 12 control individuals