tirzepatide is fda approved Diabetes Drug - Gets Approval for Weight Loss FDA Approves Tirzepatide (Zepbound) as

Hold the liquid under your tongue for a full 4 to 5 minutes before swallowing

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From a cardiovascular perspective, stacking GLP-1 agonists would likely produce additive heart rate effects, which is another reason to avoid the combination

There may also be unknown side effects of compounded tirzepatide, as it has not gone through testing like Mounjaro

Staying well-hydrated and adding fiber to the diet can also relieve constipation